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Omtrent seven-9 % af den kaukasiske befolkning har variationer i CYP2D6 genet som koder for ingen- eller nedsat aktivitet af CYP2D6 (se personlig medicin ). Tramadol et produg der omdannes til den aktive metabolit through CYP2D6. Patienter med nedsat eller manglende aktivitet af CYP2D6, vil have reduceret- eller manglende effekt af tramadol.Mælkes

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Populærkulturen romantiserer misbruget – eksperter efterlyser mere fokus på »livsfarligt stof«Therefore, opioid prescriptions in Denmark have declined due to the fact 2017. A far more nuanced method of opioid procedure for non-malignant chronic discomfort, which includes individualised therapy along with enhanced interdisciplinary collaborati

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